The Global Commission on Drug Policy report calls for the legalisation of some drugs and an end to the criminalisation of drug users.

The panel includes former UN Secretary General Kofi Annan, the former leaders of Mexico, Colombia and Brazil, and the entrepreneur Sir Richard Branson.

The US and Mexican governments have rejected the findings as misguided.

The Global Commission's 24-page report argues that anti-drug policy has failed by fuelling organised crime, costing taxpayers millions of dollars and causing thousands of deaths.

It cites UN estimates that opiate use increased 35% worldwide from 1998 to 2008, cocaine by 27%, and cannabis by 8.5%.

The 19-member commission includes Mexico's former President Ernesto Zedillo, Brazil's ex-President Fernando Henrique Cardoso and former Colombian President Cesar Gaviria, as well as the former US Federal Reserve chairman Paul Volcker and the current Prime Minister of Greece George Papandreou.

The panel also features prominent Latin American writers Carlos Fuentes and Mario Vargas Llosa, the EU's former foreign policy chief Javier Solana, and George Schultz, a former US secretary of state.

The authors criticise governments who claim the current war on drugs is effective:

"Political leaders and public figures should have the courage to articulate publicly what many of them acknowledge privately: that the evidence overwhelmingly demonstrates that repressive strategies will not solve the drug problem, and that the war on drugs has not, and cannot, be won," the report said.

Instead of punishing users who the report says "do no harm to others," the commission argues that governments should end criminalisation of drug use, experiment with legal models that would undermine organised crime syndicates and offer health and treatment services for drug-users.

It calls for drug policies based on methods empirically proven to reduce crime and promote economic and social development.